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Moreover, the pollutant concentrations in frog livers were negative functions of latitude. Monitoring changes to the glycan profiles in pharmacokinetics studies can reveal whether the clearance rates of the therapeutic antibodies depend on the different glycoforms, thereby providing useful information for improvement of the drugs. They have all been extensively studied due to their importance in neutrophil biology and immunity. Our data does however indicate that the calcium ligation sphere and the region around the heme b 3 propionates are important for proton transfer and presumably contain the proton donor. In contrast, although NO reduction is as exergonic as O2 reduction, there are no protons pumped in cNOR, and in addition, protons needed for NO reduction are derived from the periplasmic solution no contribution to the electrochemical gradient is made.

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